William Powell
— Philo Vance
Florence Eldridge
— Sibella Greene
Ullrich Haupt
— Dr. Von Blon
Jean Arthur
— Ada Greene
Eugene Pallette
— Sergeant Heath
E.H. Calvert
— John F. X. Markham
Gertrude Norman
— Mrs. Tobias Greene
Lowell Drew
— Chester Greene
Morgan Farley
— Rex Greene
Brandon Hurst
— Sproot
Augusta Burmeister
— Mrs. Mannheim
Marcia Harris
— Hemming
Veda Buckland
— Nurse (uncredited)
Shep Camp
— Medical Examiner (uncredited)
Charles E. Evans
— Lawyer Canon (uncredited)
Helena Phillips Evans
— Miss O'Brien (uncredited)
Mildred Golden
— Barton (uncredited)
Harry Strang
— Policeman (uncredited)