Danny DeVito
— George Johnson (voice)
Carrie Fisher
— Alice Conway (voice)
Richard Masur
— Michael Stevens (voice)
Rhea Perlman
— Rose Johnson (voice)
Henry Winkler
— Carl Conway (voice)
Christina Lange
— Molly Conway (voice)
Hayley Carr
— Darlene Kashitani (voice)
Lauren Taylor
— Mary O'Connell (voice)
Matthew Brooks
— Joey Fabrizio (voice)
Adrian Arnold
— Tommy Johnson (voice)
Danny Henry
— What's-His-Name (voice)
Joel Carlson
— Li'l Dom Fabrizio (voice)
Nicholas Schiavoni
— Kenny (voice)
Trish Balbert
— Angie Henderson (voice)
Alexandra Balahoutis
— Tina Edwina Farina (voice)
June Foray
— Ms. McCullough (voice)
Shepard Menken
— Additional Voices (voice)
R.J. Williams
— Additional Voices (voice)
Lindsay Parker
— Additional Voices (voice)