Kirstie Alley
— Donna Lee Shelby Thornton
Delroy Lindo
— Ricardo Thornton
Rosemary Dunsmore
— Charlotte Johnson
Kevin Duhaney
— Ricky
Catherine Fitch
— Margaret
Anna Mary Wilson
— Donna as Teen
Brittany Bristow
— Margaret as Teen
Terence Mathews
— Ricardo as Teen
Danielle Bouffard
— Donna as Kid
Gary Wilson
— Ricardo as Kid
Anastasia Hill
— Earline
Rothaford Gray
— Bruce
Victoria Adilman
— Dr. Aoki
Neville Edwards
— Garmin Watkins
Martha Burns
— Dr. Maswell
Patrice Goodman
— Supermarket Cashier
Jane Luk
— Dr. Pearl Judd
Maria Vacratsis
— Hemlock Nurse
Paul Sun-Hyung Lee
— Delivery Doctor
Katherine East
— Elliot Buillding Staff Worker #1
Marium Carvell
— Forest Haven Staff Worker