Marjorie Main
— Miss Letitia 'Tish' Carberry
Zasu Pitts
— Aggie Pilkington (as ZaSu Pitts)
Aline MacMahon
— Lizzie Wilkins
Susan Peters
— Cora Edwards Bowser
Lee Bowman
— Charles 'Charlie' Sands, Tish's Nephew
Guy Kibbee
— Judge Horace Bowser
Virginia Grey
— Katherine 'Kit' Bowser Sands
Richard Quine
— Theodore 'Ted' Bowser
Ruby Dandridge
— Violet
Howard Hickman
— Dr. Fielding Kelbridge
George Humbert
— Tony