Bea Alonzo
— Bianca (segment "Two Hearts")
John Lloyd Cruz
— Enzo (segment "Two Hearts")
Heart Evangelista
— Jackie (segment "One Love")
John Prats
— Che (segment "One Love")
Cherie Gil
— Jackie's Mom (segment "One Love")
Susan Africa
— Che's Mom (segment "One Love")
Madeleine Humphries
— Guia (segment "One Love")
Pauleen Luna
— Shanni (segment "One Love")
Anna Larrucea
— Rhoda (segment "Two Hearts")
Joel Torre
— Dante (segment "Two Hearts")
Kathleen Hermosa
— Janice (segment "Two Hearts")
Drew Arellano
— Ryan Gatmaitan (segment "One Love")
Dominic Ochoa
— Jojo (segment "Two Hearts")
Liza Lorena
— Lola (segment "Two Hearts")
Chanda Romero
— Josie (segment "Two Hearts")
John Lapus
— Tiger (segment "One Love")
Joshua Dionisio
— Xavier (segment "Two Hearts")
Bonggoy Manahan
— Jackie's Dad (segment "One Love")
Edwin Reyes
— Che's Dad (segment "One Love")
Sarita Perez de Tagle
— Celine (segment "One Love")
Dianne Tejada
— Pia (segment "One Love")
Maoui David
— Ria (segment "One Love")
Nicholas Garcia
— Edgar (segment "One Love")
Chat Silayan
— Azon (segment "Two Hearts")
Mico Palanca
— Kiko (segment "Two Hearts")
Allyzon Lualhati
— Carla (segment "Two Hearts")
Vivian Foz
— Nelly (segment "Two Hearts")
Mandy Ochoa
— Edgar (segment "Two Hearts")
Artemio Abad
— Doctor (segment "Two Hearts")