Charlie Sheen
— Dex Dogtective (voice)
Hilary Duff
— Sunshine Goodness (voice)
Eva Longoria
— Lady X (voice)
Wayne Brady
— Daredevil Dan (voice)
Christopher Lloyd
— Mr. Clipboard (voice)
Chris Kattan
— Polar Penguin (voice)
Larry Miller
— Vlad Chocool (voice)
Ed Asner
— Mr. Leonard (voice)
Jerry Stiller
— General X (voice)
Martin Klebba
— General X / Kaptain Krispy (voice)
Christine Baranski
— Hedda Shopper (voice)
Lawrence Kasanoff
— Cheasel T. Weasel (voice)
Harvey Fierstein
— Fat Cat Burglar (voice)
Cloris Leachman
— Brand X Lunch Lady (voice)
Haylie Duff
— Sweet Cakes (voice)
Shelley Morrison
— Lola Frutola (voice)
Edie McClurg
— Mrs. Butterworth (voice)
George Johnsen
— Kaptain Krispy / Hairless Hamster Henchman (voice)
Greg Ellis
— Hairy Hold (voice)
James Arnold Taylor
— Dr. Si Nustrix / Additonal Voices (voice)
Robert Costanzo
— Maximilius Moose (voice) (as Bobby Constanza)
Jeff Bennett
— Lieutenant X/Additional Voices (voice)
Stephen Stanton
— Mr. Clean / Lord Flushington / Additional Voices (voice)
Jeff Bergman
— Charlie Tuna (voice)
Karen Gallo Messore
— Blue (voice)
Sean Catherine Derek
— Toddler's Mom (voice)
Enn Reitel
— Kung Tofu / Fracois Fromage (voice)
Daniel Franzese
— Twinkleton (voice)
Eliza Schneider
— Sweet Older Lady (voice)
Jason Ortenberg
— Ike Kid #1 (voice)