Cillian Murphy
— John Skillpa / Emma Skillpa
Elliot Page
— Maggie
Susan Sarandon
— Fanny Crill
Jaimi Paige
— Wanda
Josh Lucas
— Officer Tom McGonigle
Virginia Newcomb
— Doris
Keith Carradine
— Ray Crill
Bill Pullman
— Edmund French
Graham Beckel
— Connor Black
Chris Carlson
— Neil
Eden Bodnar
— Louise Sternberg
Paul Cram
— Kenny
John Paul Gamoke
— Mr. Clapp
Joel Thingvall
— Guy in Bar (uncredited)
Nathan Christopher
— Cal