Luis Fonsi
— Captain Avispa / Jesse Vespa (voice)
Joy Huerta
— Princess Honey Bee (voice)
Juanes
— Sergeant Picadura (voice)
José Guillermo Cortines
— Jacques Puasón / Bobby Flashington / Máximo Waxon / DJ (voice)
Amelia Vega
— Polibya Néctar (voice)
Karen Martínez
— Ximena Colmena (voice)
Adalgisa Pantaleón
— Queen Ada (voice)
Roger Zayas-Bazán
— Mayor Panales (voice)
Bianca Garcia
— Aki Teriyaki (voice)
Héctor Aníbal
— Mínimo Waxon (voice)
Edwin Sanchez
— Bombo Peluca (voice)
Juan Luis Guerra
— Leo Vespa / Juan Miel Guerra (voice)