Brother John

Sidney Poitier

— John Kane

Will Geer

— Doc Thomas

Bradford Dillman

— Lloyd Thomas

Beverly Todd

— Louisa MacGill

Ramon Bieri

— Orly Ball

Warren J. Kemmerling

— George

Lincoln Kilpatrick

— Charley Gray

P. Jay Sidney

— Rev. MacGill

Richard Ward

— Frank

Paul Winfield

— Henry Birkardt

Zara Cully

— Miss Nettie

Michael Bell

— Cleve

Howard Rice

— Jimmy

Darlene Rice

— Marsha

Harry Davis

— Turnkey

Lynn Hamilton

— Sarah

Gene Tyburn

— Calvin

E.A. Nicholson

— Perry

Billy Crane

— Bill Jones (as Bill Crane)

Richard Bay

— Lab Deputy

John Hancock

— Henry's Friend

Lynn Arden

— Nurse (as Lynne Arden)

William Houze

— Motel Owner

Maye Henderson

— Neighbor

Lois Smith

— Neighbor