John Barrymore
— Chevalier Fabien des Grieux
Dolores Costello
— Manon Lescaut
Warner Oland
— André Lescaut
Sam De Grasse
— Comte Guillot de Morfontaine
Holmes Herbert
— Jean Tiberge
Stuart Holmes
— Louis XV - King of France
Bertram Grassby
— Le Duc de Richelieu
Tom Santschi
— Captain of Convict Boat
Alice Belcher
— Minor Role (uncredited)
Eugenie Besserer
— The Landlady (uncredited)
Charles Clary
— A Lay Brother (uncredited)
Marcelle Corday
— Marie (uncredited)
Rose Dione
— Nana (uncredited)
Louise Emmons
— Smiling Hag (uncredited)
Herman Heller
— Himself - Orchestra Conductor (End Credit) (uncredited)
Noble Johnson
— Aggresive Apache (uncredited)
Jack Kenny
— Minor Role (uncredited)
George Kotsonaros
— Convict Prisoner (uncredited)
Myrna Loy
— Convict Behind Manon (uncredited)
Andy MacLennan
— Man Trying to Trick Manon into His House (uncredited)
Ida May
— Minor Role (uncredited)
Kalla Pasha
— Officer on Prisoner Ship (uncredited)
Russ Powell
— Innkeeper (uncredited)
Templar Saxe
— Baron Chevral (uncredited)
Scott Seaton
— Bishop (uncredited)
Dick Sutherland
— Tavern Waiter (uncredited)
Tom Wilson
— A Convict Aboard the Boat (uncredited)