Neil Patrick Harris
— Self - Moderator
Tig Notaro
— Self
Mike Birbiglia
— Self
Atsuko Okatsuka
— Self
Gary Gulman
— Self
London Hughes
— Self
Nicole Byer
— Self
George Carlin
— Self (archive footage)
John Mulaney
— Self (archive footage)
Ali Wong
— Self (archive footage)
Paul Rodríguez
— Self (archive footage)
Richard Lewis
— Self (archive footage)
Richard Pryor
— Self (archive footage)
Mitch Hedberg
— Self (archive footage)
Howard Stern
— Self - Talk Show Host (archive footage)
Robin Quivers
— Self - Talk Show Co-Host (archive footage)
Whoopi Goldberg
— Self (archive footage)
Dick Cavett
— Self - Host, The Dick Cavett Show (archive footage)
David Letterman
— Self - Host, Late Show with David Letterman (archive footage)