Florence Reed
— Lucretia Borgia
William E. Shay
— The Duke of Ferrara
Stephen Grattan
— Lucretia's Brother
Richard Barthelmess
— Gennaro
Alex Shannon
— Rustighello
A.G. Parker
— Maffio
M.J. Briggs
— Astolpo
Edward Thorne
— Jeppo
Elmer Patterson
— Liverretto
Tony Merlo
— Petrucci
Henry Armetta
— The Jester
William Welsh
— Gubetta
Juliet Brenon
— Blanca
Jane Fearnley
— Princess Negroni
Henrietta Gilbert
— Flametta