Fred Savage
— Garfield 'Garf' Jerrniga
Ray Walston
— Matt
Sara Gilbert
— Stephie
John Clark Matthews
— Ralph the Mouse (Voice)
Conchata Ferrell
— Aunt Jill
Kellie Martin
— Karen
Summer Phoenix
— Lana
Anne Bloom
— Garf's Mother
Bruce French
— Garf's Father
Hal Smith
— Night Clerk
June Foray
— Sister Mouse (Voice)
Katie Leigh
— Cousin Mouse (Voice)
Corey Burton
— Chum (Voice)
Billy Barty
— Uncle Lester (Voice)
E'Lon Cox
— Jonathan
Edan Gross
— Merton (Voice)