Ray Romano
— Manny (voice)
John Leguizamo
— Sid (voice)
Denis Leary
— Diego (voice)
Queen Latifah
— Ellie (voice)
Simon Pegg
— Buck (voice)
Keke Palmer
— Peaches (voice)
Jennifer Lopez
— Shira (voice)
Jessie J
— Brooke (voice)
Seann William Scott
— Crash (voice)
Josh Peck
— Eddie (voice)
Adam Devine
— Julian (voice)
Nick Offerman
— Gavin (voice)
Stephanie Beatriz
— Gertie (voice)
Max Greenfield
— Roger (voice)
Chris Wedge
— Scrat (voice)
Karen Disher
— Scratte (voice)
Kari Wahlgren
— Baby Scrat (voice)