River Phoenix
— Self (archive footage)
Joaquin Phoenix
— Self (voice) (archive footage)
Danny Wallace
— Narrator
Darryl Dougherty
— River Phoenix
Michael Cooper
— Joaquin Phoenix
Jennifer Donison
— Rain Phoenix
Matthew Ebert
— Self
Dick Rude
— Self
Steve Wood
— Self
Dirk Drake
— Self
Sasa Raphael
— Self - Bassist, Aleka's Attic
Pleasant Gehman
— Self - Author & Journalist
Mike Lee
— Self - Detective Sergeant, LAPD
Dan Anderson
— Self - Toxicologist
Vinnie Scott
— Self - Paramedic
Anthony Dunn
— Flea
Julia Kulful
— Samantha Mathis
Nick Abraham
— Dick Rude
Mia Vincent
— Abby Rude
Ian McInnes
— George Sluizer
Tania Kolar
— Judy Davis
Robert Keele
— Ed Lachman
Trevor Benham
— John Frusciante
Robert Carelton
— Bouncer
Ben Bessong
— Pharmacist
Flea
— Self (archive footage)
George Sluizer
— Self - Director, Dark Blood
Edward Lachman
— Self - Cinematographer, Dark Blood
William Richert
— Self