Rachel York
— Lucille Ball
Danny Pino
— Desi Arnaz
Ann Dowd
— DeDe
Madeline Zima
— Teen Lucy
LaChanze
— Harriett
Olivia Tennet
— Lucie Arnaz (uncredited)
Rebecca Hobbs
— Vivian Vance
Mervyn Smith
— Grandpa Fred
Russell Newman
— Bill Frawley
Zoe Carides
— Lolita De Acha
Christopher Brougham
— Adult Freddy
Ray Woolf
— Ed Sedgwick
Peter Mochrie
— Don Sharpe
Andrew Robertt
— Bob Carroll Jr.
Lauchlin MacDonald
— Jess Oppenheimer
Theresa Healey
— Madelyn Pugh
Mark Clare
— Red Skelton
Vanessa Gray
— Carole Lombard
Ian Mune
— Buster Keaton
Bartholomew John
— Hubbell Robinson
James Bannon
— Lucy's Attorney (voice)
Owen Black
— Johnny
Laurie Dee
— Congressman Jackson
Alex Ewan
— Intern
Liddy Holloway
— Mildred
Paula Keenan
— Sylvia Hahlo
Charles Pierard
— Alex Hall
Peter Rowley
— Mark Daniels
Joy Watson
— Grandmother
Priscilla Bonnet
— Young Bette Davis