Willie Nelson
— Samuel Hancock
Octavia Spencer
— Black Belly
Barry Corbin
— Charlie Ledbetter
Assumpta Serna
— Cleopatra
Daniel Lapaine
— Journeyman
Dash Mihok
— Walter P. Higgs III
Arie Verveen
— Horace Marywell
Burton Gilliam
— Silas Bishop
John Beasley
— Cleofas
León Singer
— Lucio Buenstro
Christopher Dahlberg
— Dixie Little
Joe Stevens
— Ezechiel Gore
Boots Southerland
— Doc
Daniel Grant
— Bartender
James Crowley
— Jonathan Limo
Matt Bearden
— Mr. Bob
Tate Taylor
— Chester Patton
L.J. Burleson
— Frank the Thief
Bela Armendariz
— Jose Buenostro
Alex Armendariz
— Chapa Buenostro
Joey Hudgins
— Buster the Brown-Noser
Trevor Doyle Nelson
— Young Morphinist
Alex Smith
— Little Big'n
Ronnie Patilla
— Mexican Woman
Jim Dicuffa
— Older Cowboy
David Little
— Cavalry Officer
Marta Banda
— Marta Buenostro
E. Scott Perez
— The Priest
Ervin Laird
— The Skeleton Man
Juliana Sheffield
— Young Sporting Girl