Karon Riley
— Muhammad Ali
Siena Goines
— Brenda Cornelius (rumored)
Tony Grant
— James Cornelius (rumored)
RonReaco Lee
— Donald 'Nine' Rolles (rumored)
Lucius Baston
— Mr. Nottage
Shalita McFarland
— Fight Spectator
David Banner
— Bundini
Kenny Alfonso
— Agent Seeney
Keith David
— Don King
Taurus Davis
— Corner Man
Ayo Adefila
— Berbicks Corner
Ann Anderson
— Realtor
Spenser Brown
— Congo Drummer
Deena Dill
— Natalie Belmont
Stephen David Calhoun
— Gino Falsetto
Tiffany Chambers
— Ring Guest (credit only)
Gordie Daniels
— Councel Men
Angelina Cortez
— Veronica Ali
Tim Campione
— Passenger