Sam Lucas
— Uncle Tom
Irving Cummings
— George Harris
Walter Hitchcock
— George Shelby
Hattie Delaro
— Mrs. Shelby
Master Abernathy
— George Shelby Jr. as a boy
Teresa Michelena
— Eliza
Paul Scardon
— Haley
Marie Eline
— Evangeline 'Little Eva' St. Clair
Garfield Thompson
— St. Clair
Roy Applegate
— Simon Legree
Boots Wall
— Topsy