Mabel Byrne
— Jessica 'JeeJee' Santo
Emily VanCamp
— Myriam Levy
Jennifer Esposito
— Linda Santo
Aidan Quinn
— Bishop Ryan
Joshua Bowman
— Frank Belanger
Ciaran Byrne
— Fr. Luke McAteer
Robert Wahlberg
— Dr. Sam Bernard
Jeff Wiens
— Dr. Tony Messina
David Chiavaroli
— James Santo Jr.
Jessica Galinas
— Natalie Comeau
Heather Benson
— Pilgrim