Jake T. Austin
— Yankee Irving (voice)
Rob Reiner
— Screwie (voice)
William H. Macy
— Lefty Maginnis (voice)
Mandy Patinkin
— Stanley Irving (voice)
Richard Kind
— Hobo Andy / Maitre D' (voice)
Robert Wagner
— Mr. Robinson (voice)
Raven-Symoné
— Marti Brewster (voice)
Whoopi Goldberg
— Darlin' (voice)
Brian Dennehy
— Babe Ruth (voice)
Ritchie Allen
— Officer Bryant (voice)
Cherise Boothe
— Rosetta Brewster (voice)
Ralph Coppola
— Sandlot Kid #2 (voice)
Jesse Bronstein
— Sandlot Kid #1 (voice)
Jason Harris
— Announcer (voice)
Ed Helms
— Hobo Louie (voice)
Ray Iannicelli
— Conductors / Umpire (voice)
Gideon Jacobs
— Bully Kid Tubby (voice)
Marcus Maurice
— Willie (voice)
Amanda Parsons
— Emily Irving (voice)
Dana Reeve
— Emily Irving (voice)
Will Reeve
— Big Kid (voice)
Ron Tippe
— Hobo Jack (voice)
Joe Torre
— Yankees' Manager (voice)
Forest Whitaker
— Lonnie Brewster (voice)
Conor J. White
— Bully Kid Arnold (voice)
Rochelle Hogue
— Additional Voices (voice)
Sondra James
— Additional Voices (voice)
Greta Martin
— Additional Voices (voice)
Christie Moreau
— Additional Voices (voice)
Sean Oliver
— Additional Voices (voice)