Nick Stahl
— Isaac Knott
Vera Farmiga
— Fiona Ankany
Jacob Pitts
— Hugh
Aimee Mullins
— Raine
James Frain
— Father Dave
Kate Burton
— Merilee
Jessica Hecht
— Edie
Dylan Bruno
— Scott
Rachel Black
— Janice Musslewhite
Phil LaMarr
— Wannabe Group Leader
Pablo Schreiber
— Brooster
Leonardo Nam
— Engineer
Michal Sinnott
— Isaac's Mom
Joshua Leonard
— Isaac's Dad
Ashlie Atkinson
— Candy
Jeane Fournier
— Charlene Coke
Ellen Marlow
— Young Fiona
Tommy Nelson
— Young Isaac
Jamie McShane
— Man on Sidewalk
Carmela Marner
— Female Wannabe
Matthew Carey
— Male Wannabe
Ben Siegler
— Man with Trachea Tube
Gregory Dann
— Wheelchair Veteran
Josh Folan
— Raine's Dinner Date (uncredited)
Tia Dionne Hodge
— Soccer Mom (uncredited)