Sinéad Cusack
— Frances 'Frank' Kennedy
Sam Neill
— Professor Mortlock
Matthew Newton
— David Kennedy
Rose Byrne
— Jenny
Sacha Horler
— Margaret
Celia Ireland
— Peggy
Lynette Curran
— Jean
Melissa Jaffer
— Sister Sebastian
Joan Lord
— Sister Bernadette
Nic Bishop
— Mick
Deborah Kennedy
— Receptionist
Hayley McElhinney
— Francine
Annie Byron
— Eunice
Pamela Hawken
— Marcia
Brendan Higgins
— Doctor
Pamela Morrissey
— Surgeon
Christian Patterson
— Nathan
Kaitlen Patterson
— Lydia