Richard Dreyfuss
— Winston Jones
Danny Glover
— Washington Carver
Jon Heder
— Edwin Jones
Tyler Labine
— Doug Beaudin
Lesley-Ann Brandt
— Virginia Carver
Aly Michalka
— Cookie Jones
Joely Fisher
— Devon
Storm Reid
— Abigail
Lori Z. Cordova
— Nurse Millie
Angelique Chase
— Nurse Carol
Brian Kilkenny
— Boy #3
Lisa Prentiss
— Smoking Hot Stripper
BettyLynn Allison
— Mrs. Crabapple
Salena Alston
— Abigail Stand In
James Barksdale
— Crowd Extra
Dandy Barrett
— Mrs. Flemming
Maggie Batson
— Young Cookie
Kristi Booher
— Wedding Guest