Clive Brook
— Sherlock Holmes
Miriam Jordan
— Alice Faulkner
Ernest Torrence
— Professor James Moriarty
Herbert Mundin
— George
Reginald Owen
— Dr. Watson
Alan Mowbray
— Colonel Gore-King
C. Montague Shaw
— Judge
Ivan F. Simpson
— Faulkner
Roy D'Arcy
— Manuel Lopez (uncredited)
John George
— Bird Shop Thug (uncredited)
Brandon Hurst
— Secretary to Erskine (uncredited)
Howard Leeds
— Little Billy