Saffron Burrows
— Melody
Isaach de Bankolé
— Roscoe Wasz
Paz de la Huerta
— Cookie
Adam Trese
— Mr. Laffs
Janeane Garofalo
— Dr. Murray
Reg Rogers
— Brett
Elizabeth Marvel
— Ma Wilder
David Wain
— Phone Man
Bill Camp
— Pa Wilder
Richard Short
— Loser Musician
Mia Kucan
— Melody - Young
Lawrence Ballard
— Doctor
Ashlie Atkinson
— Receptionist
Larry Block
— Mr. Faddis
Lori Tan Chinn
— Mrs. Tzu
William Leroy
— Billy
Virginia Wing
— Ms. Li
Chris Bauer
— Chief of Surgery (uncredited)
Mark A. Keeton
— Guitar Salesman (uncredited)
Sonia Manzano
— Lady (uncredited)