Babe Ruth
— Babe (as George Herman 'Babe' Ruth)
Ruth Taylor
— Mildred Tobin
William Sheer
— Harry Knight
Margaret Seddon
— Babe's Mother
Frances Victory
— Pigtails
James A. Marcus
— Simon Tobin
Ralf Harolde
— John Tobin (as Ralph Harolds)
Charles Byer
— David Talmadge (as Charles Burt)
George Halpin
— Doc Hedges / The Constable / Dog Catcher
William J. Gross
— Eliar Lott
Walter Lawrence
— Tony Marino
Ann Brody
— Mrs. Tony Marino (as Anne Brodie)
Ricca Allen
— Almira Worters
Sammy Blum
— Jimbo Jones (as Sam Blum)
Ethel Kerwin
— Kitty Wilson
Tom Cameron
— Deacon Flack (as Thomas Cameron)
Charles J. Hunt
— Reverend David Talmadge