Anne Shirley
— Jean Johnson
Edward Ellis
— Dr. John Abbott
Lee Bowman
— Dick Abbott
William Henry
— Howard Sykes
John Wray
— Tom Johnson
Granville Bates
— George Sykes
Harlan Briggs
— Homer Ramsey
Frank M. Thomas
— Jode Harkness
Dickie Jones
— Dick Abbott (as a boy)
Dick Elliott
— Hank
Carole Leete
— Jean Johnson - Age 4
Gilbert Emery
— Dr. Robinson
Joe De Stefani
— Jorgensen
Barlowe Borland
— Doctor with News of Polio Outbreak (uncredited)
Maurice Costello
— Town Councilor (uncredited)
Sarah Edwards
— Clerk (uncredited)
Byron Foulger
— Bank Teller (uncredited)
Bud Geary
— Worried Father (uncredited)
Julia Griffith
— Funeral Observer (uncredited)
Charles Halton
— Atty. Clyde Perkins (uncredited)
Vinton Hayworth
— Huber (uncredited)
John Ince
— Man at Hospital Dedication (uncredited)
Lloyd Ingraham
— Funeral Observer (uncredited)
Frank Jaquet
— Funeral Observer (uncredited)
Wilfred Lucas
— Man at Hospital Dedication (uncredited)
Edmund Mortimer
— Medical Association Board Member (uncredited)
Frank O'Connor
— Man at Hospital Dedication (uncredited)
Sam Rice
— Funeral Observer (uncredited)
Larry Steers
— Medical Association Board Member (uncredited)
Grady Sutton
— Raymond (uncredited)