Sam Heughan
— Alexander
Lauren Cohan
— Leto
Sonia Enriquez
— Kali
Christopher Cazenove
— Aristotle
Kholoud Kazeem
— Niobe
Amy Shiels
— Cleopatra
Tess Spentzos
— Penelope
Paul Telfer
— Hephaestion
John Moulder-Brown
— Philip, King of Macedonia
Hala Sedki
— Olympias, Queen of Macedonia
Louis Tamone
— Thessaly