Patty Duke
— Natalie Miller
James Farentino
— David Harris
Martin Balsam
— Uncle Harold
Nancy Marchand
— Mrs. Miller
Elsa Lanchester
— Miss Dennison
Bob Balaban
— Morris
Al Pacino
— Tony
Salome Jens
— Shirley Norton
Philip Sterling
— Mr. Miller
Deborah Winters
— Betty
Ron Hale
— Harvey Belman
Ann Thomas
— Mrs Schroder
Catherine Burns
— Hester
Susan Lucci
— Cheerleader
Dagne Crane
— Diane Harris
Dennis Allen
— Max
Daniel Keyes
— Surviving Brother
Robbi Morgan
— Natalie, Age 7
Charlene Mathies
— Woman (uncredited)