Sylvia Sidney
— Jennie Gerhardt
Donald Cook
— Lester Kane
Mary Astor
— Letty Pace
Edward Arnold
— Sen. Brander
H.B. Warner
— William Gerhardt
Theodore von Eltz
— Robert Kane
Dorothy Libaire
— Louise Kane
Louise Carter
— Mrs. Gerhardt
Jane Darwell
— Boardinghouse Keeper (uncredited)
Frank Reicher
— Old Weaver (uncredited)
Betsy Ann Hisle
— Veronica Gerhardt (uncredited)
Edward LeSaint
— Lester's Doctor (uncredited)
Morgan Wallace
— O'Brien (uncredited)
Cora Sue Collins
— Vesta at Age 6