அந்நியன்

Vikram

— Ramanujam 'Ambi' Iyengar / Remo / Anniyan

Sadha

— Nandini Raghuram

Prakash Raj

— DCP Prabhakar

Vivek

— Chari Singari

Nedumudi Venu

— Parthasarathy Iyengar

Nassar

— Psychiatrist

Cochin Haneefa

— Delinquent Car Owner

Kalabhavan Mani

— House Owner

Charle

— Wastrel

Shanmugarajan

— Chockalingam

Saurabh Shukla

— Break Company Owner

Manobala

— Ticket Conductor

Shanthi Williams

— Susheela, Ambi's Mother

R. Neelakantan

— Ananthanarayanan

Sriranjini

— Nandhini's Mother

Vatsala Rajagopal

— Ambi's Grandmother

Mohan Vaidya

— Krishna

Hari Prashanth

— Young Ambi

Citizen Mani

— A cook who works under Chockalingam

Yana Gupta

— Special Appearance in "Kaadhal Yaanai" Song

Kaniha

— Nandini Raghuram (Voice)

S. N. Surendar

— Parthasarathy Iyengar (Voice)

Meera Krishnan

— Nandhini's Mother (Voice)