Tilda Swinton
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Amber Tamblyn
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Timothy Hutton
— Paul
Denis O'Hare
— Frank
Jim Gaffigan
— Joe Daley
Deirdre O'Connell
— Jane
Halley Feiffer
— Rhana
Neal Huff
— Mr. Thomas
Kel O'Neill
— Corey White
John Ellison Conlee
— Jack Hutchinson
Vincent Piazza
— Geoff
Caitlin Van Zandt
— Satin
Marceline Hugot
— Mrs. Werner
Kaiulani Lee
— Pastor
Novella Nelson
— Dr. Peterson
Melissa Leo
— Miri Daley
Constance Wu
— Jenn
Michael Nostrand
— Intern
Susan Ferrara
— Reporter #1
Jenny Nay
— Teri Thomas
Adelia Saunders
— Rhana's Sister
Harry Zittel
— Pratt
Trisha LaFache
— Karen
Jillian Cuzzolino
— Elizabeth
Gene Galusha
— Roy Gilcrest
Marion McCorry
— Mrs. Gilcrest
Ali Reza
— Mr. Scalesi
Lauren Phillips
— Jenn's House Party Goer
David Bodenschatz
— Paramedic #1