Sarita Choudhury
— Humera (segment "Honey-Getter")
Anne Heche
— Pregnant Girl (segment "Manhattan Miracle")
Taral Hicks
— Woman with Flowers (segment "Sax Cantor Riff")
Gregory Hines
— Jack (segment "Manhattan Miracle")
Danny Hoch
— Edward (segment "Honey-Getter")
Israel Horovitz
— Older Man (segment "The Listeners")
Bonnie Hunt
— Fern McDermott (segment "Fern's Heart of Darkness")
Bill Irwin
— Bill Irwin (segment "Subway Car from Hell")
Christine Lahti
— Red Shoe Woman (segment "The Red Shoes")
Denis Leary
— Wheelchair Man (segment "The Red Shoes")
Michael McGlone
— John T. (segment "Love on the A Train")
Ajay Naidu
— Prashant (segment "Honey-Getter")
KRS-One
— Vendor (segment "Subway Car from Hell")
Rosie Perez
— The Girl (segment "Love on the A Train")
Michael Rapaport
— Jake (segment "The Listeners")
Mercedes Ruehl
— Leyla (segment "Underground")
Jerry Stiller
— Old Man (segment "The 5:24")
Lili Taylor
— Belinda (segment "The Listeners")
Zachary Taylor
— Wayne (segment "Underground")
Steve Zahn
— Tucker (segment "The 5:24")
Tina North
— Grandmother (segment "Subway Car from Hell")
Paul Lazar
— Mr. Nervous (segment "Subway Car from Hell")
Andre B. Blake
— Knish Buyer (segment "Subway Car from Hell")
Anthony S. Calypso
— Knish Buyer (segment "Subway Car from Hell")
Robert W. Castle
— Knish Buyer (segment "Subway Car from Hell")
Marlon Cherry
— Musician (segment "Subway Car from Hell")
Carl J. Ferrazza
— Hot Dog Buyer (segment "Subway Car from Hell")
Daniel Freedman
— Strange Man (segment "Subway Car from Hell")
Marc Mueller
— Musician (segment "Subway Car from Hell")
Paul Mueller
— Musician (segment "Subway Car from Hell")