Brian Keith
— William Dunn
Ben Johnson
— George Bradley
John Beal
— Maj. John Wesley Powell
James Drury
— Walter Powell
R.G. Armstrong
— Oramel Howland
L.Q. Jones
— Billy Hawkins
Dan Sheridan
— Jack Sumner
Stan Jones
— Seneca Howland
David Frankham
— Frank Goodman
Roy Barcroft
— Jim Baker
Jack Big Head
— Ashtishkel
Pat Hogan
— Indian chief
Dawn Little Sky
— Indian woman
David Stollery
— Andrew 'Andy' Hall
Ray Walker
— McSpadden (uncredited)