Clifton Webb
— Howard Osborne
Charles Bickford
— Tom Reagan
Anne Francis
— Jacqueline "Jake" Osborne
William Lundigan
— Matt Reagan
Reginald Gardiner
— Roger Evans
Evelyn Varden
— Millie Reagan
Margalo Gillmore
— Claire Osborne
Tommy Rettig
— Daniel Reagan
Parley Baer
— Charlie (uncredited)
Willis Bouchey
— Dr. Lucius Brenner (uncredited)
Frank Ferguson
— Pinkie's Father (uncredited)
Selmer Jackson
— Dr. Halsey (uncredited)
Jeannie Epper
— Reagan Girl