Pat O'Brien
— Michael O'Flaherty 'Speed' McBride
Adolphe Menjou
— Kismet
Ellen Drew
— Connie McBride
Rudy Vallee
— Gordon Tolliver
Fortunio Bonanova
— Prof. Zorado
Joseph Crehan
— Dr. James P. Whitney
Jonathan Hale
— Osborne
Minna Gombell
— Aunt Sophie
Jason Robards Sr.
— Henry Fletcher
Jack Norton
— William T. Lafferty
Robert Homans
— Uncle Barney McBride (uncredited)
Tom Kennedy
— Bartender (uncredited)
Carl Switzer
— Ignatius Lafferty (uncredited)