Jane Alexander
— Calamity Jane
Frederic Forrest
— Wild Bill Hickok
Ken Kercheval
— Buffalo Bill Cody
Walter Olkewicz
— Will Lull
Talia Balsam
— Jean Irene O'Neill
Walter Scott
— Charlie Burke
David Hemmings
— Capt. James O'Neill
Isabell O'Connor
— Nell
Jack Murdock
— Rev. Warren
Larry Cedar
— Rev. Sipes
Doug Toby
— Jackie
Laurie O'Brien
— Mamie
Sara Gilbert
— Jean at Age 7
Gillian Eaton
— Mrs. O'Neill
Don Hepner
— Barker
Jessica Nelson
— Patty
Henry Kendrick
— Station Boss
Gloria Henry
— Lady
Mavis Neal Palmer
— Lady
Theresa DePaolo
— Young Woman