Lionel Barrymore
— Dr. Josiah Glass
Jean Arthur
— Maria Theresa 'Terry' O'Reilly
Chester Morris
— Jeff Crane
Joseph Calleia
— Sonny 'Dinkie' Black
Paul Kelly
— Special Agent James Duff
Lewis Stone
— Prison Warden
Paul Hurst
— Rufe Parker
George E. Stone
— Butch
Sam Baker
— Mose Jones
William Bailey
— Federal Agent (uncredited)
Brooks Benedict
— Bar Patron (uncredited)
Ed Brady
— Convict in Prison (uncredited)
Lane Chandler
— Train Conductor (uncredited)
Cora Sue Collins
— Little Girl (uncredited)
Helene Costello
— Convict Wife (uncredited)
Nell Craig
— Duff's Secretary with Telegram (uncredited)
Frank Darien
— Dr. Hale - Plastic Surgeon (uncredited)
James Flavin
— Flavin - Federal Agent (uncredited)
Harry Geise
— Convict (uncredited)
John George
— Convict (uncredited)
Jonathan Hale
— Prison Board Member (uncredited)
Henry Hall
— Restaurant Patron (uncredited)
Lillian Harmer
— Mrs. Higgins (uncredited)
Eddie Hart
— Eddie - Sonny's Henchman (uncredited)
Edward Hearn
— Policeman in Pursuing Car (uncredited)
Al Hill
— Al - Sonny's Henchman (uncredited)
Arthur Housman
— Scottsdale Bar Drunk (uncredited)
William Irving
— Federal Agent (uncredited)
Selmer Jackson
— Simpson - Prison Board Member (uncredited)
Gladden James
— Federal Agent (uncredited)