Ben Foster
— Lance Armstrong
Chris O'Dowd
— David Walsh
Guillaume Canet
— Dr. Ferrari
Jesse Plemons
— Floyd Landis
Lee Pace
— Bill Stapleton
Denis Ménochet
— Johan Bruyneel
Edward Hogg
— Frankie Andreu
Dustin Hoffman
— Bob Hamman
Elaine Cassidy
— Betsy Andreu
Laura Donnelly
— Emma O'Reilly
Peter Wight
— Sunday Times Editor
Nathan Wiley
— Charles Pelkey
Chris Larkin
— John Wilcockson
Mark Little
— Rupert Guinness
Michael G. Wilson
— Lance's Doctor
Sid Phoenix
— Tony
Josh O'Connor
— Rich
Sam Hoare
— Stephen Swart
James Harkness
— Wayne
Saskia Reeves
— Conference Director
Chloe Hayward
— Kristin
Adam LeFevre
— Jeffrey Tillotson
Brent Langdon
— Richard Faulkner
J.D. Evermore
— Tailwind Executive
Nicolas Robin
— Christophe Bassons
Julien Vialon
— John Lelangue
Chiké Okonkwo
— Young Hospital Doctor
Daniel Stewart
— Sunday Times Lawyer
Yves Aubert
— Race Official
Paul Kelleher
— Floyd Landis' Father