Danny Glover
— Silas (segment "Long Black Song")
Wesley Snipes
— George Du Vaul (segment "The Boy Who Painted Christ Black")
Lorraine Toussaint
— Philomena (segment "The Reunion")
Tate Donovan
— David (segment "Long Black Song")
Norman D. Golden II
— Aaron (segment "The Boy Who Painted Christ Black")
Susanna Thompson
— Beth Ann (segment "The Boy Who Painted Christ Black")
Jasmine Guy
— Elna Du Vaul (segment "The Boy Who Painted Christ Black")
Tina Lifford
— Sarah (segment "Long Black Song")
Carl Lumbly
— Cal (segment "The Boy Who Painted Christ Black")
Bennet Guillory
— Willie (segment "The Boy Who Painted Christ Black")
Danny Kamin
— Mr. Harper (segment "Long Black Song")
Rae'Ven Larrymore Kelly
— Lara (segment "The Boy Who Painted Christ Black")
Timothy Carhart
— Prof. Daniel (segment "The Boy Who Painted Christ Black")
Summer Ross Jefferson
— Young Philomena #1 (segment "The Boy Who Painted Christ Black")
Vanessa Bell Calloway
— Miss Williams (segment "The Boy Who Painted Christ Black")
Winter Elaine Jefferson
— Young Philomena #2 (segment "The Boy Who Painted Christ Black")
Amanda Addison
— Young Beth Ann (segment "The Boy Who Painted Christ Black")
Kevin Jamal Woods
— Clyde (segment "The Boy Who Painted Christ Black")
Ruth Beckford
— Mrs. McClaren (segment "The Boy Who Painted Christ Black")
Yolanda King
— Mrs. Crawford (segment "The Boy Who Painted Christ Black")
Douglas Cunningham
— Drummer (uncredited)
Tammy Thomas
— Waitress (uncredited)