Lou Diamond Phillips
— Jesse Rainfeather Goldman
Salli Richardson-Whitfield
— Jolene Buckley
Melinda Dillon
— Leah Goldman
Lise Cutter
— Allison
Bill Allen
— Dan Larkin
Apesanahkwat
— Clifford Rainfeather
John Dye
— Colin Adams
Gary Farmer
— Russell White
Ralph Waite
— Drew McDermott
Tantoo Cardinal
— Dawn Rainfeather
Michael Corbett
— Ray Dawes
Ronny Quintanar Jr.
— Little Jesse
Jim Great Elk Waters
— Redbow
Adam Roarke
— Douglas Goldman
Joseph Marcell
— Dr. Darryl Reichert
Earl Boen
— Andre
Van B. Poole
— Mr. Sandoval
Erik Stabenau
— Young McDermott
Cody Eagleboy
— Boy on Street
Seth Dillon
— Boy Being Inoculated
Shanti Kahn
— Leslie Baker
Ericka Bryce
— Trading Post Cashier (uncredited)