Teyonah Parris
— Lysistrata
Nick Cannon
— Demetrius 'Chi-Raq' Dupree
Wesley Snipes
— Sean 'Cyclops' Andrews
Angela Bassett
— Miss Helen Worthy
Samuel L. Jackson
— Dolmedes
John Cusack
— Fr. Mike Corridan
Jennifer Hudson
— Irene
David Patrick Kelly
— General King Kong
D.B. Sweeney
— Mayor McCloud
Dave Chappelle
— Morris
Steve Harris
— Ole Duke
Harry Lennix
— Commissioner Blades
Anya Engel-Adams
— Rasheeda
Ebony Joy
— Marcy
Erin Allen Kane
— Tee-Tee
Michelle Mitchenor
— Indigo
La La Anthony
— Hecuba
Val Warner
— Electra Johnson
Sarunas J. Jackson
— Big Mike
Corey Hendrix
— Jah
William Gines
— Armonty
Quincy Griffin
— Cairo
Chantley Lorraine Ward
— Candy
M.J. Carey
— Sergeant Toney
Samuel Robinson
— Private Alto
Anthony Fitzpatrick
— Chief Riptide
Jackie Taylor
— Olympia
Gina Breedlove
— Althea
Anthony Chisholm
— Mr. Doctor Aesop
Darren Jones
— Pindar