Babe Ruth

Stephen Lang

— George Herman 'Babe' Ruth

Brian Doyle-Murray

— Marshall Hunt

Donald Moffat

— Jacob Ruppert

Yvonne Suhor

— Helen Woodford Ruth

Bruce Weitz

— Miller Huggins

Lisa Zane

— Claire Hodgson Ruth

William Lucking

— Brother Matthias

Neal McDonough

— Lou Gehrig

Pete Rose

— Ty Cobb

Matthew Glave

— Jumpin' Joe Dugan

Adam Goldberg

— Vendor

John Anderson

— Judge Landis