Victor Garber
— John White
Paul Guilfoyle
Patrick Kilpatrick
— Amadas
Joseph Runningfox
— Wanchese
Will Sampson
— Wingina
Adrian Sparks
— Ralph Lane
Tino Juarez
— Manteo
Eddie Benton-Banai
— Tirchtough
Sherry Blakey-Banai
— Ascopo
Victoria Racimo
— Appomosiscut
Ralph Brannen
— Cossine
J. Kenneth Campbell
— Walter Ralegh
Andrew Davis
— Harriot
James Eckhouse
Giancarlo Esposito
— Simon Fernandes
Hallie Foote
— Agnes Wood
Taryn Grimes
— Eleanor
Michael Hammond
— Dare
James Bigwood
— Fisherman (uncredited)
Richard Jennings
— Griff Jones (uncredited)
Paris Peet
— Arnold Archard (uncredited)