Carroll O'Connor
— Frank Skeffington
Leslie Ackerman
— Prudy Cass
Burgess Meredith
— Cardinal Burke
John Anderson
— Amos Force
Dana Andrews
— Roger Shanley
Jack Carter
— Sam Weinberg
Mariette Hartley
— Clare Gardiner
Patrick O'Neal
— Norman Cass
Paul Picerni
— Dr. Mike Santangelo
Patrick Wayne
— Robert 'Bobby' Skeffington
Kitty Winn
— Maeve Skeffington
Robert Brown
— Nat Gardiner
Paul Laurence
— Restaurant Captain