Jesse L. Martin
— Marvin Gaye
Brendan Gleeson
— Freddy Cousaert
S. Epatha Merkerson
— Alberta Gay
Clarke Peters
— Harvey Fuqua
Vicky Krieps
— Eugenie Vis
Dwight Henry
— Marvin Gay Sr.
Rowena King
— Marilyn
Elarica Johnson
— Janis Gaye
Hana Sofia Lopes
— The groupie
Dean Gregory
— Music Journalist
Julian Nest
— Music Journalist
Martyn Berg
— Advertising Executive
Toniche Wallace
— Monica
Madyson Chretien
— Little Sister
Linda Palermo
— Herself (uncredited)
Jodie Turner-Smith
— Grace Jones