James Caan
— Professor Bernard Issaacs
Daryl Hannah
— Carmelina Trafficante
Paul Sorvino
— Jimmy Scambino
Robert Loggia
— Santino Trafficante Sr.
Armand Assante
— Vince
Robert Davi
— Big Sal - The Don
Michael Paré
— Sammy
Eric Roberts
— Detective Louis Marshall
Daniel Baldwin
— Vito
Tony Nardi
— Little Anthony (Sonny's wise guy)
Frank D'Angelo
— Santino Trafficante Jr. (Santo)
Phil Esposito
— Philly (friend of Santo's at Don Giovanni's)
Art Hindle
— Detective Domenic Durpray
Ellen Dubin
— Vince's Mistress
Tony Rosato
— Maitre D' at Don Giovanni's
George Chuvalo
— The Don's Bodyguard
Spider Jones
— The Don's Bodyguard
Nicholas Rabba
— Bar Creep