Al Pacino
— Dr. Jack Kevorkian
Danny Huston
— Geoffrey Fieger
Susan Sarandon
— Janet Good
John Goodman
— Neal Nicol
Brenda Vaccaro
— Margo Janus
Eric Lange
— John Skrzynski
James Urbaniak
— Jack Lessenberry
Rutanya Alda
— Vendor
Delaney Williams
— Detective #1
Danielle McKee
— Dorothy Lessenberry
Adam Driver
— Glen Stetson
Deirdre O'Connell
— Linda
Todd Susman
— Stan Levy
Jennifer Mudge
— Female Reporter
Jeremy Bobb
— David Rivlin
Henny Russell
— Oakhill Spokesperson
Henry Strozier
— Oakhill Doctor
Sandra Seacat
— Janet Adkins
Neil Brooks Cunningham
— Rod Adkins
David Wilson Barnes
— David Gorcyca
Cotter Smith
— Dick Thompson
John Rue
— Ray Good
Allen Lewis Rickman
— Dr. Dragovic
Kris Eivers
— Deputy
Richard Council
— Judge David Breck
Jason Babinsky
— Detective
Teresa Yenque
— Isabel Correa
Jamie Tirelli
— Trino Correa
John Henry Cox
— Mr. Kinsey
Ana Reeder
— Lynn Mills