Theda Bara
— The Vampire
Edward José
— John Schuyler
Mabel Frenyear
— John Schuyler's Wife
May Allison
— The Wife's Sister
Runa Hodges
— Schuyler Child
Clifford Bruce
— The Friend
Frank Powell
— The Doctor
Minna Gale
— The Doctor's Fiancee
Victor Benoit
— One of the Vamp's Victims
Creighton Hale
— Young Man at Wild Party (uncredited)